Aims A complex set of metabolic and inflammatory processes are involved in the
development of cardiac hypertrophy. Accumulating evidence indicates an important role for …

BACKGROUND AND PURPOSE Sirtuin 6 (SIRT6) is involved in regulation of glucose and
fat metabolism. However, its possible contribution to cardiac dysfunction remains to be …

Objective Adipose tissue is the primary site for lipid deposition that protects the organisms in
cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) …

Background: Heart failure with preserved ejection fraction (HFpEF) is a growing health
problem without effective therapies. Epidemiological studies indicate that diabetes is a …

Mitochondrial dysfunction plays an important role in obesity‐induced cardiac impairment.
SIRT 3 is a mitochondrial protein associated with increased human life span and …

Abstract Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism
and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids
via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical …

Sirtuins (Sirts) are implicated in regulating a myriad of biologic functions ranging from cell
growth and metabolism to longevity. Here, we show that nuclear Sirt, Sirt6, and …

Aims Oxidative stress contributes to the development of cardiac hypertrophy and heart
failure. One of the mitochondrial sirtuins, Sirt4, is highly expressed in the heart, but its …