Recently, it has been shown that release of cytochrome c from the mitochondria to the
cytosol is required for activation of the caspase-3-dependent cascade in apoptosis, and also …

The potential cytoprotective effects of the anti-leprosy antibiotic rifampicin were investigated
in rat pheochromocytoma (PC12) cells prior to intoxication with 1-Methyl-4-phenyl …

Treatment of human neuroblastoma SH-SY5Y cells with 1 mm1-methyl-4-phenylpyridinium
(MPP+) for 3 days induced production of reactive oxygen species (ROS), followed by …

Background The pathological features of Parkinson's disease (PD) include an abnormal
accumulation of α-synuclein in the surviving dopaminergic neurons. Though PD is …

Sporadic Parkinson's disease is associated with a defect in the activity of complex I of the
mitochondrial electron transport chain. This electron transport chain defect is transmitted …

α-Synuclein is a major component of aggregates forming amyloid-like fibrils in diseases with
Lewy bodies and other neurodegenerative disorders, yet the mechanism by which α …

Abstract α‐Synuclein is the major component of neuronal cytoplasmic aggregates called
Lewy bodies, the main pathological hallmark of Parkinson disease. Although neurons are …

The potential new iron-chelator cytisine and the radical scavenger N-tert-butyl-α-(2-
sulfophenyl) nitrone (S-PBN) were incubated in a Fenton system and hydroxyl radical …

The mitochondrial protein cytochrome c has been identified as one of the key signalling
molecules of apoptosis. In the present study, we used primary neuronal cultures to …

Overexpression of alpha-synuclein and oxidative stress has been implicated in the neuronal
cell death in Parkinson's disease. Alpha-synuclein associates with mitochondria and …