Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain
The microvascular inflow tract, comprising the penetrating arterioles, precapillary sphincters
and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly …
and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly …
[HTML][HTML] Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …
to match local energy demands. However, the specific location of microvascular flow control …
[HTML][HTML] Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo
Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper
neuronal and synaptic functioning. French physiologist Rouget was the first to describe …
neuronal and synaptic functioning. French physiologist Rouget was the first to describe …
Dysfunction of mouse cerebral arteries during early aging
Aging leads to a gradual decline in the fidelity of cerebral blood flow (CBF) responses to
neuronal activation, resulting in an increased risk for stroke and dementia. However, it is …
neuronal activation, resulting in an increased risk for stroke and dementia. However, it is …
[HTML][HTML] Emerging links between cerebral blood flow regulation and cognitive decline: A role for brain microvascular pericytes
TY You, Q Dong, M Cui - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …
the development of dementia. Recent studies have started to uncover cerebral blood flow …
[HTML][HTML] Compromised microvascular oxygen delivery increases brain tissue vulnerability with age
Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition
decline, much is still unknown about the changes in brain tissue pO2 with age. Using a …
decline, much is still unknown about the changes in brain tissue pO2 with age. Using a …
[HTML][HTML] Pericyte structural remodeling in cerebrovascular health and homeostasis
AA Berthiaume, DA Hartmann, MW Majesky… - Frontiers in aging …, 2018 - frontiersin.org
The biology of brain microvascular pericytes is an active area of research and discovery, as
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …
their interaction with the endothelium is critical for multiple aspects of cerebrovascular …
Microvascular plasticity in aging
DR Riddle, WE Sonntag, RJ Lichtenwalner - Ageing research reviews, 2003 - Elsevier
Understanding the bases of aging-related cognitive decline remains a central challenge in
neurobiology. Quantitative studies reveal little change in the number of neurons or synapses …
neurobiology. Quantitative studies reveal little change in the number of neurons or synapses …
[HTML][HTML] Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice
In age-related neurodegenerative diseases, pathology often develops slowly across the
lifespan. As one example, in diseases such as Alzheimer's, vascular decline is believed to …
lifespan. As one example, in diseases such as Alzheimer's, vascular decline is believed to …