[HTML][HTML] SARS-CoV-2 Nsp5 activates NF-κB pathway by upregulating SUMOylation of MAVS

W Li, J Qiao, Q You, S Zong, Q Peng, Y Liu… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of
clinical studies found high-level expression of pro-inflammatory cytokines in patients …

[HTML][HTML] SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

T Li, AD Kenney, H Liu, GN Fiches, D Zhou, A Biswas… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB
activation and induction of pro-inflammatory cytokines, though the underlying mechanism for …

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

Ubiquitination of SARS-CoV-2 NSP6 and ORF7a facilitates NF-κB activation

H Nishitsuji, S Iwahori, M Ohmori, K Shimotohno… - MBio, 2022 - Am Soc Microbiol
Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory
cytokines, which eventually lead to cytokine storm and the development of acute respiratory …

SARS-CoV-2 Nsp2 contributes to inflammation by activating NF-κB

É Lacasse, L Gudimard, I Dubuc, A Gravel, I Allaeys… - Viruses, 2023 - mdpi.com
COVID-19 is associated with robust inflammation and partially impaired antiviral responses.
The modulation of inflammatory gene expression by SARS-CoV-2 is not completely …

SARS-CoV-2 NSP12 protein is not an interferon-β antagonist

A Li, K Zhao, B Zhang, R Hua, Y Fang, W Jiang… - Journal of …, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is bringing an unprecedented health crisis to the …

SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response

G Guo, M Gao, X Gao, B Zhu, J Huang, K Luo… - Signal transduction and …, 2021 - nature.com
COVID-19 (Coronavirus Disease-2019), a respiratory disease caused by the novel virus
strain, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an enveloped …

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins

YX Zheng, L Wang, WS Kong, H Chen… - Acta Biochimica et …, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global
health threat since December 2019, and there is still no highly effective drug to control the …

SARS-CoV-2 switches 'on'MAPK and NFκB signaling via the reduction of nuclear DUSP1 and DUSP5 expression

S Goel, F Saheb Sharif-Askari… - Frontiers in …, 2021 - frontiersin.org
Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many
cellular processes and are essential for immune cells function. Their activity is controlled by …