Evidence for strong genetic correlations among internalizing psychopathology and related self-reported measures using both genomic and twin/adoptive approaches.
DE Gustavson, EF Stern, CA Reynolds… - … and Clinical Science, 2024 - psycnet.apa.org
The internalizing construct captures shared variance underlying risk for mood and anxiety
disorders. Internalizing factors based on diagnoses (or symptoms) of major depressive …
disorders. Internalizing factors based on diagnoses (or symptoms) of major depressive …
Internalizing and externalizing psychopathology in middle age: genetic and environmental architecture and stability of symptoms over 15 to 20 years
DE Gustavson, CE Franz, MS Panizzon… - Psychological …, 2020 - cambridge.org
BackgroundInternalizing and externalizing psychopathology factors explain much of the
covariance among psychiatric conditions, especially at the level of genetic risk. However …
covariance among psychiatric conditions, especially at the level of genetic risk. However …
Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology
BackgroundTwin studies of internalizing disorders suggest that their high co-morbidity is
partially explained by shared genetic risk. Few studies have investigated pleiotropic effects …
partially explained by shared genetic risk. Few studies have investigated pleiotropic effects …
The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood
Importance TheDSM-5classifies mood and anxiety disorders as separate conditions.
However, some studies in adults find a unidimensional internalizing factor that underpins …
However, some studies in adults find a unidimensional internalizing factor that underpins …
Strong genetic correlation between interview-assessed internalizing disorders and a brief self-report symptom scale
Self-report scales for symptoms of anxiety and depression are frequently used for screening
and research purposes. A moderate phenotypic association between disorders measured …
and research purposes. A moderate phenotypic association between disorders measured …
A broad internalizing dimension accounts for the genetic associations between personality and individual internalizing disorders.
Much research has demonstrated that psychopathology can be described in terms of broad
dimensions, representing liability for multiple psychiatric disorders. Broad spectra of …
dimensions, representing liability for multiple psychiatric disorders. Broad spectra of …
Genetic and environmental risk structure of internalizing psychopathology in youth
Abstract Background Internalizing disorders (IDs), consisting of syndromes of anxiety and
depression, are common, debilitating conditions often beginning early in life. Various trait …
depression, are common, debilitating conditions often beginning early in life. Various trait …
Central and peripheral symptoms in network analysis are differentially heritable a twin study of anxious misery
BO Olatunji, C Christian, E Strachan… - Journal of Affective …, 2020 - Elsevier
Background: Evidence suggests that depression and anxiety disorders are genetically
based. Although symptoms of these internalizing disorders tend to correlate, the degree to …
based. Although symptoms of these internalizing disorders tend to correlate, the degree to …
Genome‐wide analysis of adolescent psychotic‐like experiences shows genetic overlap with psychiatric disorders
O Pain, F Dudbridge, AG Cardno… - American Journal of …, 2018 - Wiley Online Library
This study aimed to test for overlap in genetic influences between psychotic‐like experience
traits shown by adolescents in the community, and clinically‐recognized psychiatric …
traits shown by adolescents in the community, and clinically‐recognized psychiatric …
Psychological and social risk factors associated with development of psychopathology, controlling for biological influence
J Isaksson, V Zetterqvist, M Ramklint - Current Opinion in …, 2021 - journals.lww.com
Using twin/sibling/adoptee designs, a number of unique predictors of psychopathology were
found, even when controlling for familial confounders and other specified risk factors. Future …
found, even when controlling for familial confounders and other specified risk factors. Future …