[HTML][HTML] Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia
Bruton's tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …
Integrated analysis of targeted single-cell genetic and transcriptional heterogeneity suggests novel drivers of chronic lymphocytic leukemia
Intratumoral genetic heterogeneity has been characterized across cancers, including
chronic lymphocytic leukemia (CLL), and presents challenges to therapy as presence of …
chronic lymphocytic leukemia (CLL), and presents challenges to therapy as presence of …
Comprehensive analysis of disease-related genes in chronic lymphocytic leukemia by multiplex PCR-based next generation sequencing
C Vollbrecht, FD Mairinger, U Koitzsch, M Peifer… - PloS one, 2015 - journals.plos.org
Background High resolution molecular studies have demonstrated that the clonal acquisition
of gene mutations is an important mechanism that may promote rapid disease progression …
of gene mutations is an important mechanism that may promote rapid disease progression …
Single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) to reliably detect isoform usage and coding mutations in targeted genes at a single-cell level
H Peng, JS Jabbari, L Tian, CC Chua, NS Anstee… - bioRxiv, 2024 - biorxiv.org
Single-cell long-read sequencing has transformed our understanding of isoform usage and
the mutation heterogeneity between cells. Despite unbiased in-depth analysis, the low …
the mutation heterogeneity between cells. Despite unbiased in-depth analysis, the low …
The Gene Expression Landscape of BTK Inhibitor Treatment in Chronic Lymphocytic Leukemia Exposed By Shallow Depth RNA Sequencing
Efforts to understand chronic lymphocytic leukemia (CLL) subgroups have focused on multi-
omics profiling of patient cohorts (in steady-state) and linking biomarkers to responses …
omics profiling of patient cohorts (in steady-state) and linking biomarkers to responses …
Single-Cell Long-Read Sequencing Enables the Dissection of BTK Subclonal Dynamics in CLL Treatment
Introduction: BTK inhibition is an effective frontline therapy for patients with CLL. However,
patients who develop BTK C481S mutations relapse quickly. We recently published a …
patients who develop BTK C481S mutations relapse quickly. We recently published a …
Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics
DA Landau, CJ Wu - Genome medicine, 2013 - Springer
Chronic lymphocytic leukemia (CLL) has been consistently at the forefront of genetic
research owing to its prevalence and the accessibility of sample material. Recently, genome …
research owing to its prevalence and the accessibility of sample material. Recently, genome …
Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia
Recent high-throughput sequencing and microarray studies have characterized the genetic
landscape and clonal complexity of chronic lymphocytic leukemia (CLL). Here, we …
landscape and clonal complexity of chronic lymphocytic leukemia (CLL). Here, we …
Evolution of multiple cell clones over a 29-year period of a CLL patient
Chronic lymphocytic leukaemia (CLL) is a frequent B-cell malignancy, characterized by
recurrent somatic chromosome alterations and a low level of point mutations. Here we …
recurrent somatic chromosome alterations and a low level of point mutations. Here we …
[HTML][HTML] Extensive high-depth sequencing of longitudinal CLL samples identifies frequent mutations in MAP kinase signaling and novel mutations activating notch and …
JR Gardner, MK Nahas, J He, M Patel, KM Knapp… - Blood, 2013 - Elsevier
Recent whole-genome sequencing, whole-exome sequencing, and copy number analysis
studies in small sets of patients with chronic lymphocytic leukemia (CLL) at presentation …
studies in small sets of patients with chronic lymphocytic leukemia (CLL) at presentation …