A combination hepatoma-targeted therapy based on nanotechnology: pHRE-Egr1-HSV-TK/131I-antiAFPMcAb-GCV/MFH

M Lin, J Huang, X Jiang, J Zhang, H Yu, J Ye… - Scientific Reports, 2016 - nature.com
Combination targeted therapy is a promising cancer therapeutic strategy. Here, using PEI-
Mn0. 5Zn0. 5Fe2O4 nanoparticles (PEI-MZF-NPs) as magnetic media for MFH (magnetic …

The therapeutic effect of PEI-Mn 0.5 Zn 0.5 Fe 2 O 4 nanoparticles/pEgr1-HSV-TK/GCV associated with radiation and magnet-induced heating on hepatoma

M Lin, J Huang, J Zhang, L Wang, W Xiao, H Yu, Y Li… - Nanoscale, 2013 - pubs.rsc.org
Comprehensive therapy based on the integration of hyperthermia, radiation, gene therapy
and chemotherapy is a promising area of study in cancer treatment. Using PEI-Mn0. 5Zn0 …

Egr1/HSP70 promoter-driven activation of gene expression for synergistic anti-hepatoma using PEI-MZF nanoparticles and radiation

J Zhang, M Dong, Y Feng, D Zhang, M Lin… - International Journal …, 2022 - Taylor & Francis
Introduction Spatially restricted gene expression circumvents the gene expression and gene
vector problem by enabling localized amplification. The objective of this study is to construct …

Combination of PEI-Mn0.5Zn0.5Fe2O4 nanoparticles and pHsp 70-HSV-TK/GCV with magnet-induced heating for treatment of hepatoma

Q Tang, M Lu, D Chen, P Liu - International Journal of …, 2015 - Taylor & Francis
Background To explore a new combination of thermal treatment and gene therapy for
hepatoma, a heat-inducible herpes simplex virus thymidine kinase/ganciclovir (HSV …

A Combination Therapy of pHRE‐Egr1‐HSV‐TK/Anti‐CD133McAb‐131I/MFH Mediated by FePt Nanoparticles for Liver Cancer Stem Cells

M Lin, Y Xiao, X Jiang, J Zhang, T Guo… - Journal of …, 2020 - Wiley Online Library
It has been evidenced that liver cancer stem cells (LCSCs) are to blame hepatocellular
carcinoma (HCC) occurrence, development, metastasis, and recurrence. Using iron …

Effect of recombinant plasmid pEGFP-AFP-hTNF on liver cancer cells (HepG2 cells) in vitro when delivered by PEG-PEI/Fe3O4 nanomagnetic fluid

B Zhuang, Y Zhang, J Peng, H Zhang, T Hu… - Journal of the Formosan …, 2011 - Elsevier
Background/Purpose Gene delivery into liver cancer cells has been a problem. This study
aimed to understand the effect of using PEGI/Fe 3 O 4 nanomagnetic fluid as a gene vector …

An Evaluation on Transfection Efficiency of pHRE‐Egr1‐EGFP in Hepatocellular Carcinoma Cells Bel‐7402 Mediated by PEI‐MZF‐NPs

M Lin, D Zhang, J Huang, J Zhang… - Journal of …, 2011 - Wiley Online Library
To improve transfection and expression efficiency of target gene, especially under cancer
anoxic microenvironment, we have developed pHRE‐Egr1‐EGFP/PEI‐MZF‐NPs …

Complex of TNF-α and Modified Fe3O4 Nanoparticles Suppresses Tumor Growth by Magnetic Induction Hyperthermia

P Teo, X Wang, B Chen, H Zhang, X Yang… - Cancer Biotherapy & …, 2017 - liebertpub.com
Background: Magnetic nanoparticles are increasingly applied in clinical area for drug
delivery, also in magnetic induction hyperthermia (MIH), and so on. The present research …

The anti-hepatoma effect of nanosized Mn–Zn ferrite magnetic fluid hyperthermia associated with radiation in vitro and in vivo

M Lin, D Zhang, J Huang, J Zhang, W Xiao, H Yu… - …, 2013 - iopscience.iop.org
Joint therapy is a promising area of study in cancer treatment. In this paper, we prepared Mn–
Zn ferrite (Mn 0.5 Zn 0.5 Fe 2 O 4) magnetofluid using PEI as a surfactant, and investigated …

Increased Efficacies in Magnetofection and Gene Delivery to Hepatocellular Carcinoma Cells with Ternary Organic–Inorganic Hybrid Nanocomposites

KCF Leung, CP Chak, SF Lee, JMY Lai… - Chemistry–An Asian …, 2013 - Wiley Online Library
In recent years, liver cancer (hepatocellular carcinoma) has been ranked as the leading
cancer in Asia together with lung and stomach cancers.[1, 2] Towards the treatment of …