The nuclear regulator LaeA has been shown to govern production of multiple secondary
metabolites in Aspergillus nidulans and Aspergillus fumigatus. Herein we examine the role …

Fungal secondary metabolism and morphological development have been shown to be
intimately associated at the genetic level. Much of the literature has focused on the co …

Secondary metabolites, or biochemical indicators of fungal development, are of intense
interest to humankind due to their pharmaceutical and/or toxic properties. We present here a …

Aspergillus flavus, a mycotoxigenic filamentous fungus, colonizes several important
agricultural crops, such as maize and peanuts. Two proteins, VeA and LaeA, known to form …

LaeA of Aspergillus nidulans is a putative methyltransferase and a component of the velvet
complex; it is thought to mainly affect expression of genes required for the production of …

Aspergillus flavus aflR, a gene encoding a Zn (II) 2Cys6 DNA-binding domain, is an
important transcriptional regulator of the aflatoxin biosynthesis gene cluster. Our previous …

LaeA was first identified as a novel Aspergillus nuclear protein which functions as a global
regulator of secondary metabolism, morphogenetic development, and antibiotic production …

The plant and human opportunistic fungus Aspergillus flavus is recognized for the
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …

It was long been noted that secondary metabolism is associated with fungal development. In
Aspergillus nidulans, conidiation and mycotoxin production are linked by a G protein …

The aflatoxin-producing fungi, Aspergillus flavus and A. parasiticus, form structures called
sclerotia that allow for survival under adverse conditions. Deletion of the veA gene in A …