Proteins, due to the delicate balance of stabilizing and destabilizing interactions, are only
marginally stable. Adaptation to extreme environments tends to shift the 'mesophilic' …

Discovering how organisms and their proteins adapt to extreme conditions is a complicated
process. Every condition has its own set of adaptations that make it uniquely stable in its …

Life on earth is ubiquitous within the limits from− 5 to 110° C for temperature, 0.1 to 120 MPa
for hydrostatic pressure. 1.0 to 0.6 for water activity and pH 1 to 12. In general, mutative …

Now that enzymes are available that are stable above 100° C it is possible to investigate
conformational stability at this temperature, and also the effect of high-temperature …

No organism can survive across the entire temperature range found in the biosphere, and a
given species can rarely support active metabolism across more than a few tens of° C …

Thermostability of a protein is a property which cannot be attributed to the presence of a
particular amino acid or to a post synthetic modification. Thermostability seems to be a …

Proteins represent the major components in the living cell that provide the whole repertoire
of constituents of cellular organization and metabolism. In the process of evolution …

Three complete genome sequences of thermophilic bacteria provide a wealth of information
challenging current ideas concerning phylogeny and evolution, as well as the determinants …

Publisher Summary This chapter puts the phenomenon of low-temperature instability in its
proper context and to indicate how its study might encourage new thinking about protein …

Patrick Argos,* Michael G. Rossmann, Ulrich M. Grau, 1 Herbert Zuber, Gerhard Frank, and
Jon Duri Tratschin abstract: Amino acid sequences have been compared for thermophilic …