Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …

Hepatic steatosis reflects the miRNA‐related pathological disorder with triglyceride
accumulation and lipid peroxidation, which leads to nonalcoholic steatohepatitis, liver …

Sepsis is one of the most common causes of death, which is closely related to the
uncontrolled systemic inflammation. Dysregulation of M1 macrophage polarization is the …

METHODS The effect of circRNA on miR-34a was recognized by the miRNA response
element (MRE), and validated by the dual-luciferase reporter assay. Its association with …

Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their
functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of …

Reactive oxygen species (ROS) derived from oxygen-dependent mitochondrial metabolism
are the essential drivers of cardiomyocyte (CM) cell-cycle arrest in adulthood. Mitochondria …

Prolonged parenchymal cell death leads to activation of fibrogenic cells, extracellular matrix
accumulation, and eventually liver fibrosis. Increasing evidence shows that exosomes …

Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression
and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in …

Circular RNAs (circRNAs) have important roles in several cellular processes. No study has
established the pathophysiological role for circRNAs in the heart. Here, we show that a …

The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear, where involvement
of circRNA is considered for its active role as “miRNA sponge”. Therefore, we aimed to …