Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Secondary amine pendant β-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections …

Y Qian, S Deng, Z Cong, H Zhang, Z Lu… - Journal of the …, 2022 - ACS Publications
Interest in developing antibacterial polymers as synthetic mimics of host defense peptides
(HPDs) has accelerated in recent years to combat antibiotic-resistant bacterial infections …

Infectious disease: Connecting innate immunity to biocidal polymers

GJ Gabriel, A Som, AE Madkour, T Eren… - Materials Science and …, 2007 - Elsevier
Infectious disease is a critically important global healthcare issue. In the US alone there are
2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 …

Antimicrobial polymers as synthetic mimics of host‐defense peptides

K Kuroda, GA Caputo - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
Antibiotic‐resistant bacteria 'superbugs' are an emerging threat to public health due to the
decrease in effective antibiotics as well as the slowed pace of development of new …

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides

P Salas-Ambrosio, A Tronnet, P Verhaeghe… - …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …

Strategies in translating the therapeutic potentials of host defense peptides

DSJ Ting, RW Beuerman, HS Dua… - Frontiers in …, 2020 - frontiersin.org
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

Biomimetic antimicrobial polymers: Recent advances in molecular design

C Ergene, K Yasuhara, EF Palermo - Polymer Chemistry, 2018 - pubs.rsc.org
The increasing prevalence of antibiotic-resistant bacterial infections, coupled with the
decline in the number of new antibiotic drug approvals, has created a therapeutic gap that …

Host defense (antimicrobial) peptides

E Sun, CR Belanger, EF Haney… - Peptide applications in …, 2018 - Elsevier
Small cationic, amphipathic peptides with critical roles in host defenses often exhibit
overlapping but distinct immunomodulatory activity, direct antimicrobial activity towards …

Antimicrobial macromolecules: synthesis methods and future applications

P Li, X Li, R Saravanan, CM Li, SSJ Leong - Rsc Advances, 2012 - pubs.rsc.org
This review article presents important and recent progress in the manufacture and
application of antimicrobial macromolecules. Microbial infections continue to endanger …

Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications

ON Silva, KCL Mulder, AEAD Barbosa… - Frontiers in …, 2011 - frontiersin.org
In the last few years, the number of bacteria with enhanced resistance to conventional
antibiotics has dramatically increased. Most of such bacteria belong to regular microbial …