Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in
patterns of gene expression and developmental potential as they progress from pre …

Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the
blastocyst, undergo gradual transition marked by changes in gene expression …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

The past decade has seen significant interest in the isolation of pluripotent stem cells
corresponding to various stages of mammalian embryonic development. Two distinct and …

The naïve state of pluripotency is actively being explored by a number of labs. There is some
controversy in the field as to the true identity of naïve human pluripotent cells as they are not …

Pluripotent stem cells provide a platform to interrogate control elements that function to
generate all cell types of the body. Despite their utility for modeling development and …

It has been 8 years since the concept of naïve and primed pluripotent stem cell states was
first proposed. Both are states of pluripotency, but exhibit slightly different properties. The …

Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …

After maternal predetermination gives way to zygotic regulation, a ground state is
established within the mammalian embryo. This tabula rasa for embryogenesis is present …