A panel of janus kinase inhibitors identified with anti-inflammatory effects protect mice from lethal influenza virus infection
Y Yu, S Chen, H Zhang, Y Duan, Z Li… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Influenza remains a significant threat to public health. In severe cases, excessive
inflammation can lead to severe pneumonia or acute respiratory distress syndrome …
inflammation can lead to severe pneumonia or acute respiratory distress syndrome …
Discovery and development of Janus Kinase (JAK) inhibitors for inflammatory diseases: Miniperspective
JD Clark, ME Flanagan, JB Telliez - Journal of medicinal chemistry, 2014 - ACS Publications
The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …
[HTML][HTML] A review of Janus kinase inhibitors for the treatment of Covid-19 pneumonia
Y Tanaka - Inflammation and Regeneration, 2023 - Springer
Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …
Design, synthesis, and pharmacological evaluation of 4-or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors
L Shu, C Chen, X Huan, H Huang, M Wang… - European Journal of …, 2020 - Elsevier
As non-receptor tyrosine kinases, Janus kinases (JAKs) have become an attractive target for
the treatment of autoimmune diseases and cancers. JAKs play a pivotal role in innate …
the treatment of autoimmune diseases and cancers. JAKs play a pivotal role in innate …
Structure-based design and synthesis of 1H-pyrazolo [3, 4-d] pyrimidin-4-amino derivatives as Janus kinase 3 inhibitors
Y Yin, CJ Chen, RN Yu, ZJ Wang, TT Zhang… - Bioorganic & Medicinal …, 2018 - Elsevier
Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets
for the treatment of inflammatory and immune diseases. Here we report the discovery and …
for the treatment of inflammatory and immune diseases. Here we report the discovery and …
Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1
JJ Lang, Y Lv, B Kobe, H Chen, Y Tan… - Journal of Medicinal …, 2023 - ACS Publications
Developing selective inhibitors for Janus kinase 1 (JAK1) is a significant focus for improving
the efficacy and alleviating the adverse effects in treating immune–inflammatory diseases …
the efficacy and alleviating the adverse effects in treating immune–inflammatory diseases …
Benzimidazole derivatives as potent JAK1-selective inhibitors
MK Kim, H Shin, K Park, H Kim, J Park… - Journal of Medicinal …, 2015 - ACS Publications
The Janus kinase (JAK) family comprises four members (JAK1, JAK2, JAK3, and Tyk2) that
play a key role in mediating cytokine receptor signaling. JAK inhibition thus modulates …
play a key role in mediating cytokine receptor signaling. JAK inhibition thus modulates …
[HTML][HTML] Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo
A Tanimoto, Y Ogawa, C Oki, Y Kimoto, K Nozawa… - Inflammation …, 2015 - Springer
Objective To evaluate the pharmacological properties of JTE-052, a novel Janus kinase
(JAK) inhibitor. Methods The JAK inhibitory activity of JTE-052 was evaluated using …
(JAK) inhibitor. Methods The JAK inhibitory activity of JTE-052 was evaluated using …
Identification of 2-imidazopyridine and 2-aminopyridone purinones as potent pan-janus kinase (JAK) inhibitors for the inhaled treatment of respiratory diseases
J Bach, P Eastwood, J González, E Gómez… - Journal of Medicinal …, 2019 - ACS Publications
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant
inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease …
inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease …
[HTML][HTML] In vitro and in vivo antiviral activity of gingerenone a on influenza a virus is mediated by targeting janus kinase 2
J Wang, RA Prinz, X Liu, X Xu - Viruses, 2020 - mdpi.com
Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and
primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent …
primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent …