Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Background Epigenetic alterations are strongly associated with the development of cancer.
The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) …

Background DNA methylation alterations are early events in tumorigenesis and important in
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …

Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA
methylation in gene promoter regions is a major mechanism of gene expression regulation …

Introduction The recent DNA methylation studies on cancers have revealed the necessity of
profiling an entire human genome and not to restrict the profiling to specific regions of the …

Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …

Lung cancer is the number one cause of cancer-related deaths worldwide. DNA methylation
is an epigenetic mechanism that regulates gene expression, and disease-specific …

The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …

Smoking-associated DNA hypomethylation has been observed in blood cells and linked to
lung cancer risk. However, its cause and mechanistic relationship to lung cancer remain …

DNA methylation plays a pivotal role in regulating cellular processes, and altered DNA
methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating …