Innate immune cell death in neuroinflammation and Alzheimer's disease

Y Rajesh, TD Kanneganti - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

[HTML][HTML] Innate immune activation in Alzheimer's disease

MM Wang, D Miao, XP Cao, L Tan… - Annals of translational …, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is known as the most predominant cause of dementia among the
aged people. Previously, two hallmarks of AD pathology including extracellular amyloid-β …

[HTML][HTML] Cellular and molecular mediators of neuroinflammation in Alzheimer disease

SH Yang - International neurourology journal, 2019 - ncbi.nlm.nih.gov
Alzheimer disease (AD) is a neurodegenerative disorder characterized by the loss of
neuronal cells and the progressive decline of cognitive function. The major pathological …

Friend, foe or both? Immune activity in Alzheimer's disease

GR Frost, LA Jonas, YM Li - Frontiers in Aging Neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …

Emerging roles of innate and adaptive immunity in Alzheimer's disease

X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

[HTML][HTML] The roles of inflammation and immune mechanisms in Alzheimer's disease

LJ Van Eldik, MC Carrillo, PE Cole, D Feuerbach… - Alzheimer's & Dementia …, 2016 - Elsevier
Abstract The Alzheimer's Association's Research roundtable met in April 2015 to explore the
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …

Dysregulation of systemic immunity in aging and dementia

J Lutshumba, BS Nikolajczyk… - Frontiers in Cellular …, 2021 - frontiersin.org
Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

Innate immunity and neurodegeneration

LI Labzin, MT Heneka, E Latz - Annual review of medicine, 2018 - annualreviews.org
The innate immune system plays diverse roles in health and disease. It represents the first
line of defense against infection and is involved in tissue repair, wound healing, and …

[HTML][HTML] APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease

S Parhizkar, DM Holtzman - Seminars in immunology, 2022 - Elsevier
Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …

[HTML][HTML] Inflammation as a central mechanism in Alzheimer's disease

JW Kinney, SM Bemiller, AS Murtishaw… - Alzheimer's & Dementia …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …