Mammalian axonal development begins in embryonic stages and continues postnatally.
After birth, axonal proteomic landscape changes rapidly, coordinated by transcription …

The vertebrate brain consists of diverse neuronal types, classified by distinct anatomy and
function, along with divergent transcriptomes and proteomes. Defining the cell-type specific …

Dopaminergic neurons modulate neural circuits and behaviors via dopamine (DA) release
from expansive, long range axonal projections. The elaborate cytoarchitecture of these …

Degeneration of synaptic and axonal compartments of neurons is an early event contributing
to the pathogenesis of many neurodegenerative diseases, but the underlying molecular …

Functional genomics studies through transcriptomics, translatomics and proteomics have
become increasingly important tools to understand the molecular basis of biological systems …

Healthy cortical development depends on precise regulation of transcription and translation.
However, the dynamics of how proteins are expressed, function and interact across …

Detailed observations of transcriptional, translational and post-translational events in the
human brain are essential to improving our understanding of its development, function and …

The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the
localization of the organelle in axons has been known for nearly half a century. However, the …

Phosphorylation is the most important post-translational modification of proteins in many
cells, including neurons. Phosphoproteomics is a relatively new technique for …

The immense intercellular and intracellular heterogeneity of the CNS presents major
challenges for high-throughput omic analyses. Transcriptional, translational and post …