Abstract Purpose of Review Since the mid-twentieth century, obesity and its related
comorbidities, notably insulin resistance (IR) and type 2 diabetes (T2D), have surged …

The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic
perspective, it is believed that the main cause of the high obesity rate is the mismatch …

The prevalence of obesity in modern societies has two major contributory factors—an
environmental change that has happened in historical times and a genetic predisposition …

It is hard to dispute the fact that the prevalence of overweight and obesity is increasing
around the world and that the obese are becoming more severely obese. However, there …

Obesity, diabetes, and metabolic syndrome are growing worldwide health concerns, yet their
causes are not fully understood. Research into the etiology of the obesity epidemic is highly …

Background Insulin resistance, which can lead to a number of diseases including type 2
diabetes and coronary heart disease, is believed to have evolved as an adaptation to …

Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

Obesity and type 2 diabetes arise from a set of complex gene–environment interactions.
Explanations for the heritability of these syndromes and the environmental contribution to …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk
factors for cardiovascular disease, and are destined to increase in importance given the …