Over the past decade, there has been a surge in discoveries of how metabolic pathways
regulate immune cell function in health and disease, establishing the field of …

Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in
response to viral and other infections. These alterations include changes in protein …

In recent years, the emergence of the concept of immunometabolism has shed light on the
pivotal role that cellular metabolism plays in both the activation of immune cells and the …

Viruses exploit the host and induce drastic metabolic changes to ensure an optimal
environment for replication and the production of viral progenies. In response, the host has …

Greater understanding of the complex host responses induced by type 1 interferon (IFN)
cytokines could allow new therapeutic approaches for diseases in which these cytokines are …

Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular
patterns (DAMPs) are recognized by different cellular pathogen recognition receptors …

Immune cell metabolism is dynamically regulated in parallel with the substantial changes in
cellular function that accompany immune cell activation. While these changes in metabolism …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

The immune system is a central determinant of organismal health. Functional immune
responses require quiescent immune cells to rapidly grow, proliferate, and acquire effector …

Metabolism is highly coordinated component of the cellular activity that involves sequential
chemical transformations, within a so-called metabolic network. Through these coordinated …