Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible
tissue injury, reperfusion per se may result in a local and systemic inflammatory response …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

The inflammatory response associated with myocardial and brain ischemia/reperfusion
injury (IRI) is a critical determinant of tissue necrosis, functional organ recovery, and long …

Sepsis is a clinical syndrome characterized by systemic inflammation, usually in response to
infection. The signs and symptoms are very similar to Systemic Inflammatory Response …

Reperfusion after transient tissue ischemia constitutes an irrevocable need to preserve
tissue viability. However, release of prolonged ischemia will either result in failure of the …

[Frontiers in Bioscience E1, 277-287, June 1, 2009] 277 The role of free radicals in sepsis
development Michael Everton Andrade Page 1 [Frontiers in Bioscience E1, 277-287, June 1 …

Abstract Ischaemia-Reperfusion Injury (IRI), which is often referred to as Reperfusion Injury
is the tissue damage that occurs following the return of blood flow to ischaemic tissues …

The mechanisms leading to cellular damage from ischemia-reperfusion (I/R) injury are
complex and multi-factorial. Accumulating evidence suggests an important role for oxidative …