Variation in the ability to taste bitter thiourea compounds: implications for food acceptance, dietary intake, and obesity risk in children

KL Keller, S Adise - Annual review of nutrition, 2016 - annualreviews.org
The ability to taste bitter thiourea compounds, such as phenylthiocarbamide (PTC) and 6-n-
propylthiouracil (PROP), is inherited. Polymorphisms in the bitter-taste receptor TAS2R38 …

Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4–6‐Year‐Old Children

KL Keller, A Reid, MC MacDougall, H Cassano… - …, 2010 - Wiley Online Library
Previous studies have shown that inherited taste blindness to bitter compounds like 6‐n‐
propylthiouracil (PROP) may be a risk factor for obesity, but this literature has been highly …

Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes

BJ Tepper - Annu. Rev. Nutr., 2008 - annualreviews.org
Genetic sensitivity to the bitter taste of phenylthiocarbamide and 6-n-propylthiouracil (PROP)
is a well-studied human trait. It has been hypothesized that this phenotype is a marker for …

Bitter taste phenotype and body weight predict children's selection of sweet and savory foods at a palatable test-meal

KL Keller, A Olsen, TL Cravener, R Bloom, WK Chung… - Appetite, 2014 - Elsevier
Previous studies show that children who are sensitive to the bitter taste of 6-n-
propylthiouracil (PROP) report more frequent intake of sweets and less frequent intake of …

Bitter taste perception and dietary intake patterns in irish children

SA O'Brien, EL Feeney, AGM Scannell, A Markey… - Lifestyle …, 2013 - karger.com
Abstract Background/Aims: Variations in bitter receptor gene TAS2R38 affect the perception
of bitter-tasting compound 6-n-propylthiouracil (PROP). The perception of PROP has been …

Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children

KL Keller, L Steinmann, RJ Nurse, BJ Tepper - Appetite, 2002 - Elsevier
Adult tasters of 6-n-propylthiouracil (PROP) are more sensitive to bitter taste and fattiness in
foods, and often show lower acceptance of foods that are high in these taste qualities. This …

Genetic and environmental determinants of bitter perception and sweet preferences

JA Mennella, MY Pepino, DR Reed - Pediatrics, 2005 - publications.aap.org
Objective. Flavor is the primary dimension by which young children determine food
acceptance. However, children are not merely miniature adults because sensory systems …

Genetic variation in taste sensitivity to 6‐n‐propylthiouracil and its relationship to taste perception and food selection

BJ Tepper, EA White, Y Koelliker… - Annals of the new …, 2009 - Wiley Online Library
The ability to taste bitter thiourea compounds and related chemicals is a well‐known human
trait. The majority of individuals perceive these compounds, typified by the bitterness of 6‐n …

Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation

E Roura, A Aldayyani, P Thavaraj, S Prakash… - Chemical …, 2015 - academic.oup.com
The human population displays high variation in taste perception. Differences in individual
taste sensitivity may also impact on nutrient intake and overall appetite. A well-characterized …

Inherited Taste Sensitivity to 6‐n‐Propylthiouracil in Diet and Body Weight in Children

KL Keller, BJ Tepper - Obesity research, 2004 - Wiley Online Library
Objective: Negative associations between the inherited ability to taste the bitter compound 6‐
n‐propylthiouracil (PROP) and preference for fat and body weight have been observed in …