Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections

Y Wang, S Liu, L Li, L Li, X Zhou, M Wan, P Lou… - Journal of Controlled …, 2022 - Elsevier
Cytokine storms are a primary cause of multiple organ damage and death after severe
infections, such as SARS-CoV-2. However, current single cytokine-targeted strategies …

Potential therapeutic effect of micrornas in extracellular vesicles from mesenchymal stem cells against SARS-CoV-2

JH Park, Y Choi, CW Lim, JM Park, SH Yu, Y Kim… - Cells, 2021 - mdpi.com
Extracellular vesicles (EVs) are cell-released, nanometer-scaled, membrane-bound
materials and contain diverse contents including proteins, small peptides, and nucleic acids …

Extracellular vesicles from adipose tissue-derived stem cells affect notch-miR148a-3p axis to regulate polarization of macrophages and alleviate sepsis in mice

X Bai, J Li, L Li, M Liu, Y Liu, M Cao, K Tao… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EVs) from adipose tissue-derived stem cells have been reported to
attenuate lipopolysaccharide (LPS) induced inflammation and sepsis while the specific …

Extracellular vesicle-based therapy for COVID-19: promises, challenges and future prospects

V Karn, S Ahmed, LW Tsai, R Dubey, S Ojha, HN Singh… - Biomedicines, 2021 - mdpi.com
The COVID-19 pandemic has become a serious concern and has negatively impacted
public health and the economy. It primarily targets the lungs, causing acute respiratory …

Wharton's jelly mesenchymal stem cell-derived extracellular vesicles reduce SARS-CoV2-induced inflammatory cytokines under high glucose and uremic toxin …

VC Khanh, M Fukushige, YH Chang… - Stem cells and …, 2021 - liebertpub.com
Cytokine storm is recognized as one of the factors contributing to organ failures and mortality
in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes …

[HTML][HTML] Anti‐SARS‐CoV‐2 effect of extracellular vesicles released from mesenchymal stem cells

S Chutipongtanate, S Kongsomros… - Journal of …, 2022 - ncbi.nlm.nih.gov
As of 10 December 2021, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2
accounted for 267 million people with up to 5.3 million deaths worldwide (https://covid19 …

Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis

Y Tao, X Xu, B Yang, H Zhao, Y Li - International Journal of …, 2023 - Taylor & Francis
Introduction Sepsis is a syndrome characterized by high morbidity and mortality rates. One
of its most severe complications is acute lung injury, which exhibits a multitude of clinical …

Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10

KS Park, K Svennerholm, GV Shelke… - Stem cell research & …, 2019 - Springer
Background Sepsis remains a source of high mortality in hospitalized patients despite
proper antibiotic approaches. Encouragingly, mesenchymal stromal cells (MSCs) and their …

Emerging roles of extracellular vesicles in COVID‐19, a double‐edged sword?

X Xia, P Yuan, Y Liu, Y Wang, W Cao, JC Zheng - Immunology, 2021 - Wiley Online Library
The sudden outbreak of SARS‐CoV‐2‐infected disease (COVID‐19), initiated from Wuhan,
China, has rapidly grown into a global pandemic. Emerging evidence has implicated …

[HTML][HTML] Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage

N Pillalamarri, G Ren, L Khan, A Ullah, S Jonnakuti… - Translational …, 2021 - Elsevier
Extracellular vesicles (EVs) have emerged as potential mediators of intercellular
communication. EVs are nano-sized, lipid membrane–bound vesicles that contains …