The axon-myelin unit in development and degenerative disease

RM Stassart, W Möbius, KA Nave… - Frontiers in …, 2018 - frontiersin.org
Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Myelinated axon physiology and regulation of neural circuit function

D Suminaite, DA Lyons, MR Livesey - Glia, 2019 - Wiley Online Library
The study of structural and functional plasticity in the central nervous system (CNS) to date
has focused primarily on that of neurons and synapses. However, more recent studies …

New evidence for secondary axonal degeneration in demyelinating neuropathies

KR Moss, TS Bopp, AE Johnson, A Höke - Neuroscience letters, 2021 - Elsevier
Abstract Development of peripheral nervous system (PNS) myelin involves a coordinated
series of events between growing axons and the Schwann cell (SC) progenitors that will …

Myelination of the nervous system: mechanisms and functions

KA Nave, HB Werner - Annual review of cell and developmental …, 2014 - annualreviews.org
Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system

JC Vickers, AE King, A Woodhouse, MT Kirkcaldie… - Brain research …, 2009 - Elsevier
There has been growing interest in the axon as the initial focus of pathological change in a
number of neurodegenerative diseases of the central nervous system. This review …

Oligodendrocytes: myelination and axonal support

M Simons, KA Nave - Cold Spring Harbor perspectives …, 2016 - cshperspectives.cshlp.org
Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Axonal selection and myelin sheath generation in the central nervous system

M Simons, DA Lyons - Current opinion in cell biology, 2013 - Elsevier
The formation of myelin in the central nervous system is a multi-step process that involves
coordinated cell–cell interactions and dramatic changes in plasma membrane architecture …

[HTML][HTML] Myelin in the central nervous system: structure, function, and pathology

C Stadelmann, S Timmler… - Physiological …, 2019 - journals.physiology.org
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

On myelinated axon plasticity and neuronal circuit formation and function

RG Almeida, DA Lyons - Journal of Neuroscience, 2017 - Soc Neuroscience
Studies of activity-driven nervous system plasticity have primarily focused on the gray matter.
However, MRI-based imaging studies have shown that white matter, primarily composed of …

Diversity matters: a revised guide to myelination

GS Tomassy, LB Dershowitz, P Arlotta - Trends in cell biology, 2016 - cell.com
The evolutionary success of the vertebrate nervous system is largely due to a unique
structural feature–the myelin sheath, a fatty envelope that surrounds the axons of neurons …