Background DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are
present in cells to process DNA damage and prevent genomic instability caused by various …

There is conflicting evidence as to whether individuals who are heterozygous for germ‐line
BRCA1 or BRCA2 mutations have an altered phenotypic cellular response to irradiation. To …

BRCA1 and BRCA2 genes are essential in preserving the integrity of genome, and it is not
unambiguously clear whether the heterozygosity status may affect BRCA1 or BRCA2 …

Background Breast cancer risk increases drastically in individuals carrying a germline
BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes …

The breast cancer susceptibility genes, BRCA1 and BRCA2, are used to illustrate the
application of molecular biology to clinical radiation oncology. Identified by linkage analysis …

Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1
or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the …

PURPOSE: Several in vitro studies suggest that BRCA1 and BRCA2 mutation carriers
present increased sensitivity to ionizing radiation. Different assays for the assessment of …

Purpose: The chromosomal radiosensitivity of a selected group of familial breast cancer
patients carrying a mutation in BRCA1 (n= 11) or BRCA2 (n= 9) and a group of healthy …

BRCA1 germline mutations increase the lifetime risk of developing breast and ovarian
cancers. However, taking into account the differences in disease manifestation among …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …