Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Tauopathies are age-related neurodegenerative diseases that are characterized by the
presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's
disease and related tauopathies, and the discovery that mutations in the tau gene cause …

Tau is a brain microtubule-associated protein that directly binds to a microtubule and
dynamically regulates its structure and function. Under pathological conditions, tau self …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

The tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play major regulatory roles in the organization and …

Tau is a group of neuronal microtubule-associated proteins that are formed by alternative
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain …