A narrative review: the role of NETs in acute respiratory distress syndrome/acute lung injury

X Zhou, J Jin, T Lv, Y Song - International Journal of Molecular Sciences, 2024 - mdpi.com
Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and
the alleviation and treatment of ARDS remains a major research focus. There are various …

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury

J Zhao, N Zhen, Q Zhou, J Lou, W Cui, G Zhang… - International journal of …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) threatens the survival of critically ill patients, the
mechanisms of which are still unclear. Neutrophil extracellular traps (NETs) released by …

The role of neutrophil extracellular traps in sepsis and sepsis-related acute lung injury

S Zou, H Jie, X Han, J Wang - International immunopharmacology, 2023 - Elsevier
Neutrophils release neutrophil extracellular traps (NETs) to trap pathogenic microorganisms.
NETs are involved in the inflammatory response and bacterial killing and clearance …

The role of neutrophil extracellular traps in acute lung injury

D Scozzi, F Liao, AS Krupnick, D Kreisel… - Frontiers in …, 2022 - frontiersin.org
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

S Liu, X Su, P Pan, L Zhang, Y Hu, H Tan, D Wu… - Scientific reports, 2016 - nature.com
Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens.
However, excessive NETs formation and poor degradation are associated with exacerbated …

Neutrophil extracellular traps (NETs) in severe SARS-CoV-2 lung disease

M Szturmowicz, U Demkow - International journal of molecular sciences, 2021 - mdpi.com
Neutrophil extracellular traps (NETs), built from mitochondrial or nuclear DNA, proteinases,
and histones, entrap and eliminate pathogens in the course of bacterial or viral infections …

Neutrophil extracellular traps and organ dysfunction in sepsis

S Kumar, N Payal, VK Srivastava, S Kaushik… - Clinica Chimica …, 2021 - Elsevier
Sepsis is a clinical syndrome resulting from infection followed by inflammation and is one of
the significant causes of mortality worldwide. The underlying reason is the host's …

Delayed neutrophil apoptosis may enhance NET formation in ARDS

C Song, H Li, Z Mao, L Peng, B Liu, F Lin, Y Li… - Respiratory …, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is a neutrophil-associated disease.
Delayed neutrophil apoptosis and increased levels of neutrophil extracellular traps (NETs) …

Neutrophil extracellular traps in airway diseases: Pathological roles and therapeutic implications

A Jo, DW Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis

L Luo, S Zhang, Y Wang, M Rahman… - … of Physiology-Lung …, 2014 - journals.physiology.org
Excessive neutrophil activation is a major component in septic lung injury. Neutrophil-
derived DNA may form extracellular traps in response to bacterial invasions. The aim of the …