Drivers and consequences of bacteriophage host range

D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …

Molecular and evolutionary determinants of bacteriophage host range

PA de Jonge, FL Nobrega, SJJ Brouns, BE Dutilh - Trends in microbiology, 2019 - cell.com
The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully
infect. Host range, one of the central traits to understand in phages, is determined by a range …

Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Black box of phage–bacterium interactions: Exploring alternative phage infection strategies

S Mäntynen, E Laanto, HM Oksanen… - Open …, 2021 - royalsocietypublishing.org
The canonical lytic–lysogenic binary has been challenged in recent years, as more
evidence has emerged on alternative bacteriophage infection strategies. These infection …

Phage therapy faces evolutionary challenges

C Torres-Barceló - Viruses, 2018 - mdpi.com
Antibiotic resistance evolution in bacteria indicates that one of the challenges faced by
phage therapy is that, sooner or later, bacteria will evolve resistance to phages. Evidently …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

[HTML][HTML] Bacteriophage-based tools: recent advances and novel applications

L O'sullivan, C Buttimer, O McAuliffe, D Bolton… - …, 2016 - ncbi.nlm.nih.gov
Bacteriophages (phages) are viruses that infect bacterial hosts, and since their discovery
over a century ago they have been primarily exploited to control bacterial populations and to …

The habits of highly effective phages: population dynamics as a framework for identifying therapeutic phages

JJ Bull, JJ Gill - Frontiers in microbiology, 2014 - frontiersin.org
The use of bacteriophages as antibacterial agents is being actively researched on a global
scale. Typically, the phages used are isolated from the wild by plating on the bacteria of …

Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?

C Hill, S Mills, RP Ross - Future microbiology, 2018 - Taylor & Francis
Bacteriophages, which lost out to antibiotic therapy in the past, may be poised to make a
comeback. Once discarded because of their narrow activity spectrum, it can now be viewed …

Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails

F Molina, M Menor-Flores, L Fernández… - Scientific Reports, 2022 - nature.com
The application of bacteriophages as antibacterial agents has many benefits in the “post-
antibiotic age”. To increase the number of successfully targeted bacterial strains, phage …