Global RNA modifications to the MALAT1 triple helix differentially affect thermostability and weaken binding to METTL16
MJ Schievelbein, C Resende, MM Glennon… - Journal of Biological …, 2024 - ASBMB
Therapeutic mRNAs are generated using modified nucleotides, namely N 1-
methylpseudouridine (m 1 Ψ) triphosphate, so that the mRNA evades detection by the …
methylpseudouridine (m 1 Ψ) triphosphate, so that the mRNA evades detection by the …
Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA
JA Brown, CG Kinzig… - Proceedings of the …, 2016 - National Acad Sciences
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a cancer-promoting
long noncoding RNA, accumulates in cells by using a 3′-triple-helical RNA stability …
long noncoding RNA, accumulates in cells by using a 3′-triple-helical RNA stability …
Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix
JA Brown, CG Kinzig, SJ DeGregorio, JA Steitz - Rna, 2016 - rnajournal.cshlp.org
Triple-stranded RNA was first deduced to form in vitro more than 50 years ago and has since
been implicated in RNA catalysis, stability, and small molecule binding. Despite the …
been implicated in RNA catalysis, stability, and small molecule binding. Despite the …
Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix
JA Brown, D Bulkley, J Wang, ML Valenstein… - Nature structural & …, 2014 - nature.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly abundant
nuclear long noncoding RNA that promotes malignancy. A 3′-stem-loop structure is …
nuclear long noncoding RNA that promotes malignancy. A 3′-stem-loop structure is …
Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1
FA Abulwerdi, W Xu, AA Ageeli… - ACS chemical …, 2019 - ACS Publications
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1, mouse/human),
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …
Structural insights into the RNA methyltransferase domain of METTL16
A Ruszkowska, M Ruszkowski, Z Dauter, JA Brown - Scientific reports, 2018 - nature.com
Abstract N 6-methyladenosine (m6A) is an abundant modification in messenger RNA and
noncoding RNAs that affects RNA metabolism. Methyltransferase-like protein 16 (METTL16) …
noncoding RNAs that affects RNA metabolism. Methyltransferase-like protein 16 (METTL16) …
A highly ordered, nonprotective MALAT1 ENE structure is adopted prior to triplex formation
MJ Yonkunas, NJ Baird - RNA, 2019 - rnajournal.cshlp.org
The 3′ end of the∼ 7 kb lncRNA MALAT1 contains an evolutionarily and structurally
conserved element for nuclear expression (ENE) which confers protection from cellular …
conserved element for nuclear expression (ENE) which confers protection from cellular …
Locked Nucleic Acid Oligonucleotides Facilitate RNA•LNA-RNA Triple-Helix Formation and Reduce MALAT1 Levels
KM Shivakumar, G Mahendran, JA Brown - International Journal of …, 2024 - mdpi.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and multiple endocrine
neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking …
neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking …
Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability In Vitro
M Zafferani, JG Martyr, D Muralidharan… - ACS chemical …, 2022 - ACS Publications
The rapidly accelerating characterization of RNA tertiary structures has revealed their
pervasiveness and active roles in human diseases. Small molecule-mediated modulation of …
pervasiveness and active roles in human diseases. Small molecule-mediated modulation of …
Structural analysis of MALAT1 long noncoding RNA in cells and in evolution
A Monroy-Eklund, C Taylor, CA Weidmann, C Burch… - RNA, 2023 - rnajournal.cshlp.org
Although not canonically polyadenylated, the long noncoding RNA MALAT1 (metastasis-
associated lung adenocarcinoma transcript 1) is stabilized by a highly conserved 76-nt triple …
associated lung adenocarcinoma transcript 1) is stabilized by a highly conserved 76-nt triple …