In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

Comparisons of gene expression between human and non-human primate brains have
identified hundreds of differentially expressed genes, yet translating these lists into key …

Background There is evidence that genes and their protein products are organized into
functional modules according to cellular processes and pathways. Gene co-expression …

Background A genome-wide comparative analysis of human and mouse gene expression
patterns was performed in order to evaluate the evolutionary divergence of mammalian …

Different experimental technologies measure different aspects of a system and to differing
depth and breadth. High-throughput assays have inherently high false-positive and false …

Background Network concepts are increasingly used in biology and genetics. For example,
the clustering coefficient has been used to understand network architecture; the connectivity …

Motivation: Although many network inference algorithms have been presented in the
bioinformatics literature, no suitable approach has been formulated for evaluating their …

Because mouse models play a crucial role in biomedical research related to the human
nervous system, understanding the similarities and differences between mouse and human …

Gene co-expression networks capture biological relationships between genes and are
important tools in predicting gene function and understanding disease mechanisms. We …

To understand the regulation of tissue-specific gene expression, the GTEx Consortium
generated RNA-seq expression data for more than thirty distinct human tissues. This data …