[HTML][HTML] Identifying multicellular spatiotemporal organization of cells with SpaceFlow

H Ren, BL Walker, Z Cang, Q Nie - Nature communications, 2022 - nature.com
One major challenge in analyzing spatial transcriptomic datasets is to simultaneously
incorporate the cell transcriptome similarity and their spatial locations. Here, we introduce …

[HTML][HTML] SPACEL: deep learning-based characterization of spatial transcriptome architectures

H Xu, S Wang, M Fang, S Luo, C Chen, S Wan… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies detect mRNA expression in single cells/spots
while preserving their two-dimensional (2D) spatial coordinates, allowing researchers to …

DeepST: identifying spatial domains in spatial transcriptomics by deep learning

C Xu, X Jin, S Wei, P Wang, M Luo, Z Xu… - Nucleic Acids …, 2022 - academic.oup.com
Recent advances in spatial transcriptomics (ST) have brought unprecedented opportunities
to understand tissue organization and function in spatial context. However, it is still …

Cell clustering for spatial transcriptomics data with graph neural networks

J Li, S Chen, X Pan, Y Yuan, HB Shen - Nature Computational Science, 2022 - nature.com
Spatial transcriptomics data can provide high-throughput gene expression profiling and the
spatial structure of tissues simultaneously. Most studies have relied on only the gene …

[HTML][HTML] Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder

K Dong, S Zhang - Nature communications, 2022 - nature.com
Recent advances in spatially resolved transcriptomics have enabled comprehensive
measurements of gene expression patterns while retaining the spatial context of the tissue …

[HTML][HTML] Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

D Pham, X Tan, J Xu, LF Grice, PY Lam, A Raghubar… - BioRxiv, 2020 - biorxiv.org
Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and
tissue morphology to the genome-wide transcriptional profile of cells in an undissociated …

Identifying spatial domains of spatially resolved transcriptomics via multi-view graph convolutional networks

X Shi, J Zhu, Y Long, C Liang - Briefings in Bioinformatics, 2023 - academic.oup.com
Motivation: Recent advances in spatially resolved transcriptomics (ST) technologies enable
the measurement of gene expression profiles while preserving cellular spatial context …

[HTML][HTML] Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

D Pham, X Tan, B Balderson, J Xu, LF Grice… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

STRIDE: accurately decomposing and integrating spatial transcriptomics using single-cell RNA sequencing

D Sun, Z Liu, T Li, Q Wu, C Wang - Nucleic Acids Research, 2022 - academic.oup.com
The recent advances in spatial transcriptomics have brought unprecedented opportunities to
understand the cellular heterogeneity in the spatial context. However, the current limitations …