Background Musculoskeletal disorder (MSD) are a class of inflammatory and degener‐ative
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …

RNA modifications have emerged as key regulators of transcript expression in diverse
physiological and pathological processes. As one of the most prevalent types of RNA …

Thus far, there are more than known 150 modifications to RNA, in which common internal
modifications of mRNA include N6-methyladenosine (m6A), N1-methyladenosine, and 5 …

Objective To study the N6-methyladenosine (m 6 A) modification pattern of nucleus
pulposus (NP) tissue during intervertebral disc degeneration (IDD). Methods A standing …

Abstract N 6-methyladenosine (m 6 A), a novel epitranscriptomic RNA modification, plays
crucial roles in a variety of biological processes and diseases. Recently, there are growing …

Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and
elderly people. However, current treatment for OA in its early stages is ineffective, and drug …

Rheumatoid arthritis (RA) is a systemic autoimmune disease for which the etiology has not
been fully elucidated. Previous studies have shown that the development of RA has genetic …

Increasing evidence suggest the biological roles of N6-methyladenosine (m6A) and long
noncoding RNAs (lncRNAs) in the bone disease, especially osteoarthritis (OA). However …

Methylation is the most common posttranscriptional modification in cellular RNAs, which has
been reported to modulate the alteration of RNA structure for initiating relevant functions …

Background The intervertebral disc (IVD) degeneration is the leading cause of low back
pain, which accounts for a main cause of disability. N6‐methyladenosine (m6A) is the most …