Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2

Y Zhu, J Li, P Zhang, B Peng, C Li, Y Ming, H Liu - PeerJ, 2023 - peerj.com
Background During hepatic ischemia-reperfusion injury, the excessive release of
inflammatory cytokines can activate the intracellular signal transduction cascade to induce …

Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2

L Sun, X Chen, S Zhu, J Xu, X Li, S Diao… - Acta Pharmacologica …, 2024 - nature.com
Acute liver injury (ALI) is a complex, life-threatening inflammatory liver disease, and
persistent liver damage leads to rapid decline and even failure of liver function. However …

CircRNA-Phf21a_0002 promotes pyroptosis to aggravate hepatic ischemia/reperfusion injury by sponging let-7b-5p

P Jiang, X Li, Y Shen, L Luo, B Wu, D Teng, J Wang… - Heliyon, 2024 - cell.com
Hepatic ischemia‒reperfusion injury is a common injury in liver surgery and liver
transplantation that can lead to liver function damage, including oxidative stress, apoptosis …

Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury

P Zhang, Y Ming, Q Ye, Y Niu - Scientific Reports, 2019 - nature.com
Ischemic postconditioning (IPO) attenuates hepatic ischemia/reperfusion (I/R) injury. The
aim of this study was to explore the role of circular RNAs (circRNAs) in the protective …

Monotropein alleviates septic acute liver injury by restricting oxidative stress, inflammation, and apoptosis via the AKT (Ser473)/GSK3β (Ser9)/Fyn/NRF2 pathway

K Xie, F Wang, Y Yang, S Pan, J Wang, N Xiao… - International …, 2024 - Elsevier
Sepsis-associated acute liver injury (ALI) is a deadly condition resulting from a systemic
inflammatory response to liver cell damage and malfunction. Monotropein (MON) belongs to …

[HTML][HTML] Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway

Q Yu, S Chen, H Tang, X Zhang, R Tao, Z Yan… - International …, 2021 - Elsevier
Oxidative stress following liver ischemia/reperfusion (I/R) is an important pathological
mechanism responsible for liver injury. Veratric acid (VA) is a phenolic benzoic acid that has …

Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway

H Li, Y Chen, M Ding, Z Yan, W Guo, R Guo - Chemico-biological …, 2023 - Elsevier
Hepatic ischemia/reperfusion (I/R) injury is an unavoidable complication of liver
hepatectomy, transplantation, and systemic shock. Pectolinarigenin (Pec) is a flavonoid with …

[HTML][HTML] Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the …

ZJ Feng, LS Wang, X Ma, K Li, XY Li, Y Tang… - Molecular …, 2023 - Elsevier
Background Hepatic ischemia-reperfusion (I/R) injury involves inflammatory necrosis of liver
cells as a significant pathological mechanism. Catapol possesses anti-inflammatory activity …

Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice

L Yang, S Yu, Y Yang, H Wu, X Zhang, Y Lei… - Bioorganic & Medicinal …, 2022 - Elsevier
Liver injury mediated by endoplasmic reticulum (ER) stress can cause many kinds of liver
diseases including hepatic glucose and lipid metabolic disorders, and long term liver injury …

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

JM Dai, WN Guo, YZ Tan, KW Niu… - Journal of cellular …, 2021 - Wiley Online Library
Sepsis is a life‐threatening organ dysfunction syndrome, and liver is a susceptible target
organ in sepsis, because the activation of inflammatory pathways contributes to septic liver …