The fetal inflammatory response syndrome

R Gomez, R Romero, F Ghezzi, BH Yoon… - American journal of …, 1998 - Elsevier
OBJECTIVE: The objective of this study was to determine the frequency and clinical
significance of a systemic inflammatory response as defined by an elevated plasma …

A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition

R Romero, R Gomez, F Ghezzi, BH Yoon… - American journal of …, 1998 - Elsevier
OBJECTIVE: There is no evidence for the participation of the human fetus in the
mechanisms responsible for the onset of preterm labor. We propose that preterm labor in the …

Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery

KD Wenstrom, WW Andrews, JC Hauth… - American journal of …, 1998 - Elsevier
OBJECTIVE: Our purpose was to determine whether early second-trimester amniotic fluid
interleukin-6 levels predict delivery before 34 weeks' gestation. STUDY DESIGN: We used …

Evidence for fetal involvement in the pathologic process of clinical chorioamnionitis

T Chaiworapongsa, R Romero, JC Kim, YM Kim… - American journal of …, 2002 - Elsevier
Objective: Clinical and histologic chorioamnionitis have recently been identified as risk
factors for cerebral palsy. Proinflammatory cytokines have been implicated in the …

Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity

BH Yoon, R Romero, CJ Kim, JK Jun, R Gomez… - American journal of …, 1995 - Elsevier
OBJECTIVE: Our purpose was to determine whether amniotic fluid concentrations of
interleukin-6 are of value in the antenatal diagnosis of acute inflammatory lesions (histologic …

The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates

N Hofer, R Kothari, N Morris, W Müller… - American journal of …, 2013 - Elsevier
Objective The aim of this study was to show and discuss an association between fetal
inflammatory response syndrome (FIRS) and an adverse neonatal outcome defined as …

Maternal serum interleukin-6 during pregnancy and during term and preterm labor

PC Greig, AP Murtha, CJ Jimmerson, WNP Herbert… - Obstetrics & …, 1997 - Elsevier
Objective: To determine the normal concentrations of maternal serum interleukin-6 during
the second and third trimesters of pregnancy and the different stages of term and preterm …

Maternal serum interleukin-6, C-reactive protein, and matrix metalloproteinase-9 concentrations as risk factors for preterm birth< 32 weeks and adverse neonatal …

Y Sorokin, R Romero, L Mele… - American journal of …, 2010 - thieme-connect.com
Elevated concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and matrix
metalloproteinase-9 (MMP-9) in fetal and neonatal compartments have been associated …

Maternal serum interleukin-6 concentration as a marker for impending preterm delivery

AP Murtha, PC Greig, CE JIMMERSON… - Obstetrics & …, 1998 - journals.lww.com
Methods: Blood samples were collected from 130 gravidas at 22-34 weeks' gestation. The
study group consisted of 89 women evaluated for preterm contractions or premature rupture …

Cytokines in noninvasively obtained amniotic fluid as predictors of fetal inflammatory response syndrome

M Kunze, M Klar, CA Morfeld, B Thorns… - American journal of …, 2016 - Elsevier
Background In patients with preterm premature rupture of membranes, intrauterine
inflammation and/or infection is frequently present, can lead to fetal inflammatory response …