Since the advent of insulin, the improvements in diabetes detection and the therapies to treat
hyperglycemia have reduced the mortality of acute metabolic emergencies, such that today …

Type 2 diabetes mellitus (DM) is increasing around the world, and the public health impact
of DM, driven largely by cardiovascular disease complications, underpins the importance of …

Diabetes mellitus results in severe cardiovascular complications, and heart disease and
failure remain the major causes of death in patients with diabetes. Given the increasing …

Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease (CVD)
morbidity and mortality worldwide. Renin-angiotensin system (RAS) blockers have been …

Type 2 diabetes mellitus is becoming a major health problem associated with excess
morbidity and mortality. As the prevalence of type 2 diabetes is rapidly increasing …

Hypertension increases the risk of type 2 diabetes mellitus (T2DM) and cardiovascular
disease. In addition to lowering blood pressure, blockade of the renin–angiotensin …

The phylogenetically old renin‐angiotensin‐system (RAS) was originally described as a
circulating hormonal system and a main cardiovascular regulator. However, there also exist …

The prevalence of diabetes has reached epidemic proportions in the developed world and is
expect to increase to 5.4% by 2025. This has resulted in an unprecedented number of …

Type 2 diabetes is a complex chronic disease with increasing microvascular and
macrovascular complications imposing a significant public health and economic burden [1] …

Diabetes mellitus is a leading cause of morbidity and mortality because of its cardiovascular
complications. It has been suggested that hyperglycemia, hyperinsulinemia and insulin …