Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite
survival and proliferation. Invasion is mediated by multiple ligands, which could be …

Blood-stage malaria vaccines that target single Plasmodium falciparum antigens involved in
erythrocyte invasion have not induced optimal protection in field trials. Blood-stage malaria …

Plasmodium falciparum merozoites use diverse alternative erythrocyte receptors for invasion
and variably express cognate ligands encoded by the erythrocyte binding antigen (eba) and …

A highly-effective, long-lasting vaccine, targeting multiple stages of the Plasmodium
falciparum life cycle, is likely to be important for the elimination of this pathogen. Key …

Central to the pathology of malaria disease are the repeated cycles of parasite invasion and
destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species …

Background A highly effective vaccine against Plasmodium falciparum malaria should
induce potent, strain transcending immunity that broadly protects against the diverse …

The clinical manifestations of Plasmodium falciparum malaria are directly linked to the blood
stage of the parasite life cycle. At the blood stage, the circulating merozoites invade …

Having the ability to rapidly, accurately, and robustly measure Plasmodium falciparum
merozoite invasion is a critical component in effective assessment of a blood stage vaccine's …

Further understanding of the molecular mediators of alternative RBC invasion phenotypes in
endemic malaria parasites will support malaria blood-stage vaccine or drug development …

Infection with the protozoan parasitePlasmodium falciparum results in the severest form of
human malaria. The symptoms and pathology of malaria occur during the intra-erythrocytic …