Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

B Canal, AW McClure, JF Curran, M Wu… - Biochemical …, 2021 - portlandpress.com
SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world
causing a deadly pandemic with tremendous social and economic costs. Healthcare …

[HTML][HTML] Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors

AA Riccio, ED Sullivan, WC Copeland - Journal of Biological Chemistry, 2022 - ASBMB
Understanding the core replication complex of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is essential to the development of novel coronavirus-specific …

[HTML][HTML] The nsp15 nuclease as a good target to combat SARS-CoV-2: mechanism of action and its inactivation with FDA-approved drugs

M Saramago, VG Costa, CS Souza, C Bárria… - Microorganisms, 2022 - mdpi.com
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2

NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

[HTML][HTML] Identifying small-molecule inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase by establishing a fluorometric assay

X Bai, H Sun, S Wu, Y Li, L Wang, B Hong - Frontiers in Immunology, 2022 - frontiersin.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the
coronavirus family, appeared in 2019 and has caused the largest global public health and …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

J Zeng, F Weissmann, AP Bertolin, V Posse… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

CT Lim, KW Tan, M Wu, R Ulferts… - Biochemical …, 2021 - portlandpress.com
The COVID-19 pandemic has emerged as the biggest life-threatening disease of this
century. Whilst vaccination should provide a long-term solution, this is pitted against the …

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

S Lin, H Chen, Z Chen, F Yang, F Ye… - Nucleic acids …, 2021 - academic.oup.com
The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

AP Bertolin, F Weissmann, J Zeng, V Posse… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest
public health and economic crisis in recent history impacting virtually all sectors of society …

Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs

N Narayanan, DT Nair - International Journal of Biological Macromolecules, 2021 - Elsevier
SARS-CoV-2is the causative agent for the ongoing COVID19 pandemic, and this virus
belongs to the Coronaviridae family. The nsp14 protein of SARS-CoV-2 houses a 3′ to 5 …