Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity …

Purpose The heterogeneity in sepsis is held responsible, in part, for the lack of precision
treatment. Many attempts to identify subtypes of sepsis patients identify those with shared …

Background Subphenotypes have been identified within heterogeneous diseases such as
asthma and breast cancer, with important therapeutic implications. We assessed whether …

A healthy body activates the immune response to target invading pathogens (ie viruses,
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …

Objectives: Classification of patients with acute respiratory distress syndrome into hyper-and
hypoinflammatory subphenotypes using plasma biomarkers may facilitate more effective …

Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis …

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

Although much progress has been made in ARDS phenotyping, implementation of precision
medicine practices will depend on conducting phenotype-aware trials using rapid point of …