A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues

MM Halstead, C Kern, P Saelao, Y Wang… - BMC genomics, 2020 - Springer
Background Although considerable progress has been made towards annotating the
noncoding portion of the human and mouse genomes, regulatory elements in other species …

Chromatin accessibility and regulatory vocabulary across indicine cattle tissues

PA Alexandre, M Naval-Sánchez, M Menzies… - Genome biology, 2021 - Springer
Background Spatiotemporal changes in the chromatin accessibility landscape are essential
to cell differentiation, development, health, and disease. The quest of identifying regulatory …

Profiling of chromatin accessibility in pigs across multiple tissues and developmental stages

J Bai, Y Lin, J Zhang, Z Chen, Y Wang, M Li… - International Journal of …, 2023 - mdpi.com
The study of chromatin accessibility across tissues and developmental stages is essential for
elucidating the transcriptional regulation of various phenotypes and biological processes …

Multi-species annotation of transcriptome and chromatin structure in domesticated animals

S Foissac, S Djebali, K Munyard, N Vialaneix, A Rau… - BMC biology, 2019 - Springer
Background Comparative genomics studies are central in identifying the coding and non-
coding elements associated with complex traits, and the functional annotation of genomes is …

Functional annotation of the cattle genome through systematic discovery and characterization of chromatin states and butyrate-induced variations

L Fang, S Liu, M Liu, X Kang, S Lin, B Li, EE Connor… - BMC biology, 2019 - Springer
Background The functional annotation of genomes, including chromatin accessibility and
modifications, is important for understanding and effectively utilizing the increased amount of …

[HTML][HTML] Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits

XN Zhu, YZ Wang, C Li, HY Wu, R Zhang… - Zoological …, 2023 - ncbi.nlm.nih.gov
The development of epigenetic maps, such as the ENCODE project in humans, provides
resources for gene regulation studies and a reference for research of disease-related …

Transcription initiation mapping in 31 bovine tissues reveals complex promoter activity, pervasive transcription, and tissue-specific promoter usage

DE Goszczynski, MM Halstead, AD Islas-Trejo… - Genome …, 2021 - genome.cshlp.org
Characterizing transcription start sites is essential for understanding the regulatory
mechanisms that control gene expression. Recently, a new bovine genome assembly (ARS …

Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle

L Fang, W Cai, S Liu, O Canela-Xandri, Y Gao… - Genome …, 2020 - genome.cshlp.org
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated …

Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research

C Kern, Y Wang, X Xu, Z Pan, M Halstead… - Nature …, 2021 - nature.com
Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

An atlas of bovine gene expression reveals novel distinctive tissue characteristics and evidence for improving genome annotation

GP Harhay, TPL Smith, LJ Alexander… - Genome Biology, 2010 - Springer
Background A comprehensive transcriptome survey, or gene atlas, provides information
essential for a complete understanding of the genomic biology of an organism. We present …