OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy

DM Emms, S Kelly - Genome biology, 2015 - Springer
Identifying homology relationships between sequences is fundamental to biological
research. Here we provide a novel orthogroup inference algorithm called OrthoFinder that …

OrthoFinder: phylogenetic orthology inference for comparative genomics

DM Emms, S Kelly - Genome biology, 2019 - Springer
Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder's
high accuracy orthogroup inference to provide phylogenetic inference of orthologs, rooted …

Algorithm of OMA for large-scale orthology inference

ACJ Roth, GH Gonnet, C Dessimoz - BMC bioinformatics, 2008 - Springer
Background OMA is a project that aims to identify orthologs within publicly available,
complete genomes. With 657 genomes analyzed to date, OMA is one of the largest projects …

Improving the specificity of high-throughput ortholog prediction

DL Fulton, YY Li, MR Laird, BGS Horsman… - BMC …, 2006 - Springer
Background Orthologs (genes that have diverged after a speciation event) tend to have
similar function, and so their prediction has become an important component of comparative …

[PDF][PDF] OrthoFinder2: fast and accurate phylogenomic orthology analysis from gene sequences

DM Emms, S Kelly - BioRxiv, 2018 - scholar.archive.org
Ortholog inference has fundamental importance across the biological sciences,
underpinning phylogenetics, comparative genomics and prediction of gene function. We …

Integrating gene annotation with orthology inference at scale

BM Kirilenko, C Munegowda, E Osipova, D Jebb… - Science, 2023 - science.org
Annotating coding genes and inferring orthologs are two classical challenges in genomics
and evolutionary biology that have traditionally been approached separately, limiting …

[HTML][HTML] Standardized benchmarking in the quest for orthologs

AM Altenhoff, B Boeckmann, S Capella-Gutierrez… - Nature …, 2016 - nature.com
Achieving high accuracy in orthology inference is essential for many comparative,
evolutionary and functional genomic analyses, yet the true evolutionary history of genes is …

Orthologous Matrix (OMA) algorithm 2.0: more robust to asymmetric evolutionary rates and more scalable hierarchical orthologous group inference

CM Train, NM Glover, GH Gonnet, AM Altenhoff… - …, 2017 - academic.oup.com
Motivation Accurate orthology inference is a fundamental step in many phylogenetics and
comparative analysis. Many methods have been proposed, including OMA (Orthologous …

OMA Browser—exploring orthologous relations across 352 complete genomes

A Schneider, C Dessimoz, GH Gonnet - Bioinformatics, 2007 - academic.oup.com
Motivation: Inference of the evolutionary relation between proteins, in particular the
identification of orthologs, is a central problem in comparative genomics. Several large-scale …

Evaluating ortholog prediction algorithms in a yeast model clade

L Salichos, A Rokas - PloS one, 2011 - journals.plos.org
Background Accurate identification of orthologs is crucial for evolutionary studies and for
functional annotation. Several algorithms have been developed for ortholog delineation, but …