A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

R Jayadev, MRPT Morais, JM Ellingford… - Science …, 2022 - science.org
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

Basement membranes

R Jayadev, DR Sherwood - Current Biology, 2017 - cell.com
Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled
extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs …

Kidney organoids recapitulate human basement membrane assembly in health and disease

MRPT Morais, P Tian, C Lawless, S Murtuza-Baker… - Elife, 2022 - elifesciences.org
Basement membranes (BMs) are complex macromolecular networks underlying all
continuous layers of cells. Essential components include collagen IV and laminins, which …

Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding

DP Keeley, E Hastie, R Jayadev, LC Kelley, Q Chi… - Developmental cell, 2020 - cell.com
Basement membranes (BMs) are supramolecular matrices built on laminin and type IV
collagen networks that provide structural and signaling support to tissues. BM complexity …

Basement membranes: cell scaffoldings and signaling platforms

PD Yurchenco - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

New concepts in basement membrane biology

W Halfter, P Oertle, CA Monnier, L Camenzind… - The FEBS …, 2015 - Wiley Online Library
Basement membranes (BMs) are thin sheets of extracellular matrix that outline epithelia,
muscle fibers, blood vessels and peripheral nerves. The current view of BM structure and …

Basement membrane remodeling guides cell migration and cell morphogenesis during development

DR Sherwood - Current opinion in cell biology, 2021 - Elsevier
Basement membranes (BMs) are thin, dense forms of extracellular matrix that underlie or
surround most animal tissues. BMs are enormously complex and harbor numerous proteins …

α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes

R Jayadev, Q Chi, DP Keeley, EL Hastie… - Journal of Cell …, 2019 - rupress.org
Basement membranes (BMs) are cell-associated extracellular matrices that support tissue
integrity, signaling, and barrier properties. Type IV collagen is critical for BM function, yet …

A systems-level study reveals regulators of membrane-less organelles in human cells

D Berchtold, N Battich, L Pelkmans - Molecular cell, 2018 - cell.com
Membrane-less organelles (MLOs) are liquid-like subcellular compartments that form
through phase separation of proteins and RNA. While their biophysical properties are …

Transcriptome-based systematic identification of extracellular matrix proteins

R Manabe, K Tsutsui, T Yamada… - Proceedings of the …, 2008 - National Acad Sciences
Extracellular matrix (ECM), which provides critical scaffolds for all adhesive cells, regulates
proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs …