The metastatic potential of cells is an important parameter in the design of optimal strategies
for the personalized treatment of cancer. Using atomic force microscopy (AFM), we show …

Cancer cells are defined by their ability to invade through the basement membrane, a critical
step during metastasis. While increased secretion of proteases, which facilitates degradation …

Alterations in the biomechanical properties and cytoskeletal organization of cancer cells in
addition to genetic changes have been correlated with their aggressive phenotype. In this …

Background Cell stiffness is a crucial mechanical property that is closely related to cell
motility. AFM is the most prevalent method used to determine cell stiffness by the quantitative …

Increased tissue stiffness is a classic characteristic of solid tumors. One of the major
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …

There is growing appreciation of the importance of the mechanical properties of the tumor
microenvironment on disease progression. However, the role of extracellular matrix (ECM) …

The stiffness of tumor cells varies during cancer progression. In particular, metastatic
carcinoma cells analyzed by Atomic Force Microscopy (AFM) appear softer than non …

Initiation and development of cancer are usually accompanied by alterations in the cellular
mechanical properties such as its stiffness and viscosity. Understanding the viscoelasticity of …

Recently biomechanics of cancer cells, in particular stiffness or elasticity, has been identified
as an important factor relating to cancer cell function, adherence, motility, transformation and …

Ovarian cancer is an extremely lethal gynecologic disease; with the high-grade serous
subtype predominantly associated with poor survival rates. Lack of early diagnostic …