The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …
prevalence worldwide owing to different dietary patterns and medication use. Despite …
Discovery and refinement of loci associated with lipid levels
Nature genetics, 2013 - nature.com
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
[HTML][HTML] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Recent genome-wide association (GWA) studies of lipids have been conducted in samples
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …
[HTML][HTML] Whole genome sequence analysis of blood lipid levels in> 66,000 individuals
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …
Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease
Most genome-wide association studies have been of European individuals, even though
most genetic variation in humans is seen only in non-European samples. To search for …
most genetic variation in humans is seen only in non-European samples. To search for …
[PDF][PDF] Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
FW Asselbergs, Y Guo, EPA Van Iperen… - The American Journal of …, 2012 - cell.com
Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
AR Bentley, YJ Sung, MR Brown, TW Winkler… - Nature …, 2019 - nature.com
The concentrations of high-and low-density-lipoprotein cholesterol and triglycerides are
influenced by smoking, but it is unknown whether genetic associations with lipids may be …
influenced by smoking, but it is unknown whether genetic associations with lipids may be …
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
[HTML][HTML] Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …