KRAB zinc finger proteins

G Ecco, M Imbeault, D Trono - Development, 2017 - journals.biologists.com
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …

The role of KRAB-ZFPs in transposable element repression and mammalian evolution

P Yang, Y Wang, TS Macfarlan - Trends in Genetics, 2017 - cell.com
Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

PY Helleboid, M Heusel, J Duc, C Piot… - The EMBO …, 2019 - embopress.org
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFP s) are encoded in the
hundreds by the genomes of higher vertebrates, and many act with the heterochromatin …

Take a walk on the KRAB side

O Rosspopoff, D Trono - Trends in Genetics, 2023 - cell.com
Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

M Imbeault, PY Helleboid, D Trono - Nature, 2017 - nature.com
The human genome encodes some 350 Krüppel-associated box (KRAB) domain-containing
zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been …

Transposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues

G Ecco, M Cassano, A Kauzlaric, J Duc, A Coluccio… - Developmental cell, 2016 - cell.com
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …

KRAB-zinc finger proteins: a repressor family displaying multiple biological functions

A Lupo, E Cesaro, G Montano, D Zurlo, P Izzo… - Current …, 2013 - ingentaconnect.com
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the
largest individual family of transcriptional repressors encoded by the genomes of higher …

The arms race between KRAB–zinc finger proteins and endogenous retroelements and its impact on mammals

M Bruno, M Mahgoub… - Annual Review of …, 2019 - annualreviews.org
Nearly half of the human genome consists of endogenous retroelements (EREs) and their
genetic remnants, a small fraction of which carry the potential to propagate in the host …

KRAB–zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading

AC Groner, S Meylan, A Ciuffi, N Zangger… - PLoS …, 2010 - journals.plos.org
Krüppel-associated box domain-zinc finger proteins (KRAB–ZFPs) are tetrapod-specific
transcriptional repressors encoded in the hundreds by the human genome. In order to …

Genetic features and genomic targets of human KRAB-zinc finger proteins

J de Tribolet-Hardy, CW Thorball, R Forey… - Genome …, 2023 - genome.cshlp.org
Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of
the largest groups of transcription factors encoded by tetrapods, with 378 members in …