Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls

S Battaglia, C Nazzi, TB Lonsdorf, JF Thayer - Molecular Psychiatry, 2024 - nature.com
In the last century, the paradigm of fear conditioning has greatly evolved in a variety of
scientific fields. The techniques, protocols, and analysis methods now most used have …

[HTML][HTML] Fear-induced bradycardia in mental disorders: Foundations, current advances, future perspectives

S Battaglia, C Nazzi, JF Thayer - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Fear-induced bradycardia, a transient heart rate deceleration related to a threatening event,
is a powerful technique used to assess fear conditioning in humans. During the last century …

Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain

S Battaglia, C Nazzi, JF Thayer - Translational psychiatry, 2024 - nature.com
Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is
a physiological index observable in humans, especially in fear conditioning experiments …

Characterizing cardiac autonomic dynamics of fear learning in humans

S Battaglia, S Orsolini, S Borgomaneri… - …, 2022 - Wiley Online Library
Understanding transient dynamics of the autonomic nervous system during fear learning
remains a critical step to translate basic research into treatment of fear‐related disorders. In …

Attentive immobility in the face of inevitable distal threat—Startle potentiation and fear bradycardia as an index of emotion and attention

C Szeska, J Richter, J Wendt, M Weymar… - …, 2021 - Wiley Online Library
During fear conditioning, a cue (CS) signals an inevitable distal threat (US) and evokes a
conditioned response that can be described as attentive immobility (freezing). The organism …

Conditioned and extinguished fear modulate functional corticocardiac coupling in humans

C Panitz, C Hermann, EM Mueller - Psychophysiology, 2015 - Wiley Online Library
Although the conditioned cardiac fear response is an important index of psychophysiological
fear processing, underlying neural mechanisms remain unclear. N= 22 participants …

A review on how stress modulates fear conditioning: Let's not forget the role of sex and sex hormones

C Peyrot, A Brouillard, S Morand-Beaulieu… - Behaviour Research and …, 2020 - Elsevier
Stress and fear are two fields of research that have evolved simultaneously. It was not until
the eighties that these domains converged in order to better characterize the impact of stress …

Modeling fear‐conditioned bradycardia in humans

G Castegnetti, A Tzovara, M Staib, PC Paulus… - …, 2016 - Wiley Online Library
Across species, cued fear conditioning is a common experimental paradigm to investigate
aversive Pavlovian learning. While fear‐conditioned stimuli (CS+) elicit overt behavior in …

Functional interplay between central and autonomic nervous systems in human fear conditioning

S Battaglia, JF Thayer - Trends in Neurosciences, 2022 - cell.com
Historically, studies on the neural basis of fear conditioning have emphasized the role of the
central nervous system. However, there is growing evidence for the role of the autonomic …

Cardiac defense response as a predictor of fear learning

R López, R Poy, MC Pastor, P Segarra… - International Journal of …, 2009 - Elsevier
Prior studies have demonstrated that differences in activation of the defensive motivational
system–as indexed by cardiac responses to the CS+ during aversive conditioning–are …