The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

Resolution of inflammation: An organizing principle in biology and medicine

D Panigrahy, MM Gilligan, CN Serhan… - Pharmacology & …, 2021 - Elsevier
The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Pro-resolving lipid mediators are leads for resolution physiology

CN Serhan - Nature, 2014 - nature.com
Advances in our understanding of the mechanisms that bring about the resolution of acute
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

CN Serhan, N Chiang, J Dalli - Molecular aspects of medicine, 2018 - Elsevier
While protective, the acute inflammatory response when uncontrolled can lead to further
tissue damage and chronic inflammation that is now widely recognized to play important …

[HTML][HTML] Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

CN Serhan - The American journal of pathology, 2010 - Elsevier
Because inflammation is appreciated as a unifying basis of many widely occurring diseases,
the mechanisms involved in its natural resolution are of considerable interest. Using …

[HTML][HTML] Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

CN Serhan - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Lipid mediators in the resolution of inflammation

CN Serhan, N Chiang, J Dalli… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

CN Serhan, N Chiang, TE Van Dyke - Nature Reviews Immunology, 2008 - nature.com
Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Specialized pro-resolving lipid mediators in the inflammatory response: An update

G Bannenberg, CN Serhan - … et Biophysica Acta (BBA)-Molecular and Cell …, 2010 - Elsevier
A new genus of specialized pro-resolving mediators (SPM) which include several families of
distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in …

Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Y Isobe, T Kato, M Arita - Frontiers in immunology, 2012 - frontiersin.org
Acute inflammation and its resolution are essential processes for tissue protection and
homeostasis. Once thought to be a passive process, the resolution of inflammation is now …