Currently, the clinically approved repertoire of antiviral drugs predominantly comprises direct-
acting antivirals (DAAs). However, the use of DAAs is frequently limited by adverse effects …

Abstract Objective Cardiovascular diseases (CVDs) are the leading cause of mortality in
Western countries. Atherosclerosis is a multi-step inflammatory disease characterized at …

Under the influences of modern lifestyle, metabolic syndromes (MetS), including insulin
resistance, obesity, and fatty liver, featuring a worldwide chronic disease, greatly raise the …

Aberrant cholesterol metabolism and homeostasis in the form of elevated cholesterol
biosynthesis and dysregulated efflux and metabolism is well recognized as a major feature …

The nuclear receptor RORγ is a major driver of autoimmune diseases and certain types of
cancer due to its aberrant function in T helper 17 (Th17) cell differentiation and tumor …

In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a
potential therapeutic measure against viral infections. Our rationale for targeting RNA viral …

Retinoid-related orphan receptors (RORs), including the α, β and γ isoforms (NR1F1–3), are
orphan nuclear receptors that have been implicated in tissue development, immune …

Nuclear receptors (NR) are ligand-regulated transcription factors that bind DNA in proximity
to their target genes and exert their effects as a result of binding by small molecule ligands …

Maintaining lipid homeostasis is crucial to liver function, the key organ that governs the
whole-body energy metabolism. In contrast, lipid dysregulation has been implicated in …

Nuclear receptors (NRs) are ligand-regulated transcription factors that display canonical
domain structure with highly conserved DNA-binding and ligand-binding domains. The …