Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Genome-wide association study identifies eight loci associated with blood pressure

C Newton-Cheh, T Johnson, V Gateva, MD Tobin… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

LV Wain, GC Verwoert, PF O'reilly, G Shi, T Johnson… - Nature …, 2011 - nature.com
Numerous genetic loci have been associated with systolic blood pressure (SBP) and
diastolic blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide …

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

GB Ehret, T Ferreira, DI Chasman, AU Jackson… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Genome-wide association study of blood pressure and hypertension

D Levy, GB Ehret, K Rice, GC Verwoert, LJ Launer… - Nature …, 2009 - nature.com
Blood pressure is a major cardiovascular disease risk factor. To date, few variants
associated with interindividual blood pressure variation have been identified and replicated …

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

TJ Hoffmann, GB Ehret, P Nandakumar, D Ranatunga… - Nature …, 2017 - nature.com
Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

A Giri, JN Hellwege, JM Keaton, J Park, C Qiu… - Nature …, 2019 - nature.com
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

Advances in blood pressure genomics

PB Munroe, MR Barnes, MJ Caulfield - Circulation research, 2013 - Am Heart Assoc
The elucidation of genes implicated in Mendelian forms of hypertension demonstrates rare
variants with substantial effects are responsible, and often these genes lie within pathways …

Loci influencing blood pressure identified using a cardiovascular gene-centric array

SK Ganesh, V Tragante, W Guo, Y Guo… - Human molecular …, 2013 - academic.oup.com
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To
investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial …