Historically, the evidences of safety and efficacy that companies provide to regulatory
agencies as support to the request for marketing authorization of a new medical product …

Different research communities have developed various approaches to assess the credibility
of predictive models. Each approach usually works well for a specific type of model, and …

The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …

The present publication surveys several applications of in silico (ie, computational)
toxicology approaches across different industries and institutions. It highlights the need to …

Highlights•In silico models facilitate the expert to evaluate toxicity, analyzing results of a
battery of models.•In silico models can address among others, the presence of structural …

The term 'in silico clinical trials indicates the use of individualised computer simulation in the
development or regulatory evaluation of a medicinal product, medical device, or medical …

Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …

The percentage of failures in late pharmaceutical development due to toxicity has increased
dramatically over the last decade or so, resulting in increased demand for new methods to …

Current preclinical safety evaluation programs use a combination of computational methods,
mechanistic in vitro screening and–primarily–in vivo experimentation to predict human …

With the rapidly growing and aging world population comes an urgent and rising demand for
new and better drugs. Many observers feel that the pharmaceutical industry seems unable to …