Apple-shaped obesity: a risky soil for cytokine-accelerated severity in COVID-19

T Hosoya, S Oba, Y Komiya… - Proceedings of the …, 2023 - National Acad Sciences
Obesity has been recognized as one of the most significant risk factors for the deterioration
and mortality associated with COVID-19, but the significance of obesity itself differs among …

[HTML][HTML] Upregulation of inflammatory genes and pathways links obesity to severe COVID-19

J Currey, C Ellsworth, MS Khatun, C Wang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Obesity is a risk factor for developing severe COVID-19. However, the mechanism
underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a …

The obesity paradox predicts the second wave of COVID-19 to be severe in Western countries

IA Krams, P Jõers, S Luoto, G Trakimas… - International journal of …, 2021 - mdpi.com
While COVID-19 infection and mortality rates are soaring in Western countries, Southeast
Asian countries have successfully avoided the second wave of the SARS-CoV-2 pandemic …

Commentary: COVID-19 and obesity: exploring biologic vulnerabilities, structural disparities, and weight stigma

MJ Townsend, TK Kyle… - Metabolism-Clinical and …, 2020 - metabolismjournal.com
Obesity has emerged as a risk factor for hospitalization, intensive care, and mortality among
patients with COVID-19 [1–9]. These risk signals persist after adjusting for age, sex, and …

COVID-19 and obesity: dangerous liaisons

G Caci, A Albini, M Malerba, DM Noonan… - Journal of clinical …, 2020 - mdpi.com
Besides advanced age and the presence of multiple comorbidities as major contributors to
increased risk of severe disease and fatal outcome from Severe Acute Respiratory …

Obesity as a risk factor for severe COVID-19 and complications: a review

F Demeulemeester, K de Punder, M van Heijningen… - Cells, 2021 - mdpi.com
Emerging data suggest that obesity is a major risk factor for the progression of major
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …

Obesity and COVID-19: what makes obese host so vulnerable?

S Mohammad, R Aziz, S Al Mahri, SS Malik, E Haji… - Immunity & …, 2021 - Springer
Abstract The disease (COVID-19) novel coronavirus pandemic has so far infected millions
resulting in the death of over a million people as of Oct 2020. More than 90% of those …

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

YN Zhang, ZR Zhang, HQ Zhang, XD Li, JQ Li… - Cell Discovery, 2021 - nature.com
Dear Editor, Since the outbreak in later 2019, the cofirmed COVID-19 cases have surpassed
162 million, with more than 3 million deaths around the world (https://covid19. who. int) …

Epidemiological and immunological features of obesity and SARS-CoV-2

EJ Nilles, SM Siddiqui, S Fischinger, YC Bartsch… - Viruses, 2021 - mdpi.com
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk
of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly …

COVID-19 severity in obese patients: Potential mechanisms and molecular targets for clinical intervention

JR Sharma, UCS Yadav - Obesity Research & Clinical Practice, 2021 - Elsevier
With the global spread of SARS-CoV-2, millions of people have been affected leading to the
declaration of coronavirus disease 2019 (COVID-19) as a pandemic by the WHO. Several …