Rhamnetin is a better inhibitor of SARS-CoV-2 2'-O-methyltransferase than dolutegravir: a computational prediction

B Adekunle, AN Oli, OA Onuh, NW Emeter… - African Journal of …, 2022 - ajol.info
Background: The 2'-O-methyltransferase is responsible for the capping of SARS-CoV-2
mRNA and consequently the evasion of the host's immune system. This study aims at …

African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2′-O-ribose methyltransferase: an in silico perspective

GA Gyebi, OM Ogunyemi, AA Adefolalu… - Journal of Molecular …, 2022 - Elsevier
Despite the ongoing vaccination against the life-threatening COVID-19, there is need for
viable therapeutic interventions. The S-adenosyl-l-Methionine (SAM) dependent 2-O'-ribose …

In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase

A Chandra, M Chaudhary, I Qamar… - Journal of …, 2022 - Taylor & Francis
The novel Coronavirus disease 2019 (COVID-19) is potentially fatal and caused by Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the unavailability of any …

Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 …

TP Saliu, HI Umar, OJ Ogunsile, MO Okpara… - Journal of Genetic …, 2021 - Elsevier
Background Since the index case was reported in China, COVID-19 has led to the death of
at least 4 million people globally. Although there are some vaccine cocktails in circulation …

Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16)

M Kumar, A Roy, RS Rawat, A Alok… - Journal of …, 2022 - Taylor & Francis
Pathogenic RNA viruses are emerging as one of the major threats and posing challenges to
human community. RNA viruses have an exceptionally shorter generation time and easy to …

In silico screening of phytochemical compounds and FDA drugs as potential inhibitors for NSP16/10 5' methyl transferase activity

A Malik, M Kohli, NA Jacob, A Kayal… - Journal of …, 2023 - Taylor & Francis
The recent global pandemic associated with the highly contagious novel coronavirus (SARS-
CoV-2) has led to an unpredictable loss of life and economy worldwide, and the discovery of …

[PDF][PDF] Virtual screening and molecular docking of FDA approved antiviral drugs for the identification of potential inhibitors of SARS-CoV-2 RNA-MTase protein

S Jaan, S Waheed, S Bashir, MS Javed… - Int. J. Adv. Biol …, 2021 - researchgate.net
ABSTRACT Background: SARS-CoV-2 is a novel coronavirus discovered in December 2019
and is responsible for pandemic disease COVID-19. In the absence of any available …

Computational guided drug repurposing for targeting 2′-O-ribose methyltransferase of SARS-CoV-2

K Sharma, S Morla, A Goyal, S Kumar - Life Sciences, 2020 - Elsevier
Aims The recent outbreak of pandemic severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has led the world towards a global health emergency. Currently, no proper …

Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus

A Sulimov, D Kutov, I Ilin, Y Xiao, S Jiang, V Sulimov - Molecules, 2022 - mdpi.com
The COVID-19 pandemic is still affecting many people worldwide and causing a heavy
burden to global health. To eliminate the disease, SARS-CoV-2, the virus responsible for the …

Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus

Y Jiang, L Liu, M Manning, M Bonahoom… - Journal of …, 2022 - Taylor & Francis
Abstract SARS-CoV-2, an emerging coronavirus, has spread rapidly around the world,
resulting in over ten million cases and more than half a million deaths as of July 1, 2020 …