B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies
characterized by abnormal proliferation of immature lymphoid cells. It is the most commonly …

Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known
major genetic subtypes, while a substantial proportion of BCP ALL remains poorly …

In childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), cytogenetic
abnormalities remain important diagnostic and prognostic tools. A number of well …

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …

B-lymphoblastic leukemia/lymphoma, also known as B-acute lymphoblastic leukemia, is
derived from B-cell progenitors. B-acute lymphoblastic leukemia occurs predominantly in …

During the last decade a tremendous technologic progress based on genome-wide profiling
of genetic aberrations, structural DNA alterations, and sequence variations has allowed a …

Abstract Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic
leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes …

Background The t (9; 22) and t (4; 11) chromosomal translocations, which generate the BCR-
ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia …

Acute lymphoblastic leukaemia (ALL) remains a leading cause of non‐traumatic death in
children, and the majority of adults diagnosed will succumb to the disease. Recent advances …